Ann Graybiel

Institute Professor

Massachusetts Institute of Technology

United States

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Research Interests

Behavioral Neuroscience

100%

Cognitive Neuroscience

40%

Addiction Neuroscience

50%

Reward Processing

40%

Neuropharmacology

30%

Basal Ganglia

30%

Neurodegenerative Disease

30%

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Articles15

Molecular Imbalances Between Striosome and Matrix Compartments Characterize the Pathogenesis and Pathophysiology of Huntington’s Disease Model Mouse

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Year:

2025

Surprises From the Basal Ganglia: Stop and Go Have New Meaning

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Year:

2025

Cingulate microstimulation induces negative decision-making via reduced top-down influence on primate fronto-cingulo-striatal network

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Year:

2024

CalDAG-GEFI acts as a guanine nucleotide exchange factor for LRRK2 to regulate LRRK2 function and neurodegeneration

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Year:

2024

Representation of rhythmic chunking in striatum of mice executing complex continuous movement sequences

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Year:

2024

Transcriptional vulnerabilities of striatal neurons in human and rodent models of Huntington’s disease

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Year:

2023

Multiplexed action-outcome representation by striatal striosome-matrix compartments detected with a mouse cost-benefit foraging task

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Year:

2022

Effects of acute and repeated administration of the selective M4 PAM VU0152099 on cocaine versus food choice in male rats

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Year:

2022

Cannabinoid Receptor 1 Is Required for Neurodevelopment of Striosome-Dendron Bouquets.

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Year:

2022

Computational phenotyping of brain-behavior dynamics underlying approach-avoidance conflict in major depressive disorder

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Year:

2021

Striatal transcriptome changes linked to drug-induced repetitive behaviors.

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Year:

2021

CalDAG-GEFI mediates striatal cholinergic modulation of dendritic excitability, synaptic plasticity and psychomotor behaviors.

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Year:

2021

The Role of the Dorsal-Lateral Prefrontal Cortex in Reward Sensitivity During Approach-Avoidance Conflict.

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Year:

2021

Causal Evidence for Induction of Pessimistic Decision-Making in Primates by the Network of Frontal Cortex and Striosomes.

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Year:

2021

Spatiotemporal Up-Regulation of Mu Opioid Receptor 1 in Striatum of Mouse Model of Huntington's Disease Differentially Affecting Caudal and Striosomal Regions.

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Year:

2020

Collaborators10

Ryoma Morigaki

Tokushima University

JAPAN

Jianzhong Yu

UNITED STATES

Ferah Yildirim

Assistant professor

Charité - Universitätsmedizin Berlin

GERMANY

Walker Jackson

Senior lecturer

Linköping University

SWEDEN

Manolis Kellis

Professor

Massachusetts Institute of Technology

UNITED STATES

Mriganka Sur

Massachusetts Institute of Technology

UNITED STATES

Ken-ichi Amemori

特定拠点准教授 / Program-Specific Research Center Associate Professor

Kyoto University

JAPAN

Rafiq Huda

Rutgers University

UNITED STATES

Morgane Thomsen

Københavns Universitet

DENMARK

Michael Frank

Brown University

UNITED STATES

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